Wayans was born in New York City, he is the nephew of iconic uncles Keenan, Damon, Shawn and Marlon Wayans.
Damien began his career in 1987 inEddie Murphy's concert film Eddie Murphy Raw. He later acted with his uncle Damon Wayans in the movie “Major Payne”, which led to television roles in such primetime series as “New York Undercover”, “ NYPD Blues” and “House MD” among others. Working on critically acclaimed shows at a young age spawned his appetite to write and direct. In the years to follow Damien played a key role in his uncle Damon's sitcom “My Wife and Kids” as Writer, Director and Producer.
As he shaped his writing and directing career, he continued to indulge his acting abilities and landed a breakout role inJamie Kennedy's film Malibu's Most Wanted as “Tec”. He then went on to share the spotlight with notable actors such as Morgan Freeman, Kevin Spacey and Justin Timberlake in the movie – “Edison” and Ben Affleck in “Man About Town” to name a few.
Soon after, trending, in the footsteps of his uncles, Damien wrote, directed and produced on The Underground, asketch comedy show on Showtime.Which led to his Motion Picture Feature Directorial Debut with the filmDance Flick, which was also written and executive produced by Damien.
With serveral years of consecutive work, under his belt in both television and film as a quadruple threat, the talented Actor, Writer, Director and Producer began his own Production Company “Second Generation Productions”. The company is focused on producing new cutting edge content for film, television and web.In 2012 Second Generation Productions signed a deal with BET networks, to bring you the highly anticipated “Second Generation Wayans”,starring Damien Dante Wayans along with cousin Craig Wayans. In this hilarious, new, scripted comedy viewers see the good, the funny and the ugly as the young duo emerges from the long shadows of their uncles to carve out their own paths in Hollywood. “Second Generations Wayans” launches January 15 2013.